Located in Busan, Korea, is the Department of Pediatrics at Kosin University Gospel Hospital.
The Department of Dermatology at Kosin University Gospel Hospital in Busan, Korea, is also available for consultations.
This article is openly accessible and can be shared under the Creative Commons Attribution Non-Commercial License, allowing for unrestricted use and distribution with proper citation.
The details of this study are published in the Korean Journal of Pediatrics 2013;56(6):260-264, with an online publication date of June 21, 2013.
Abstract
A young boy in Korea, aged 11, experienced various symptoms after being treated with dapsone (4,4′-diaminodiphenylsulfone, DDS), an effective anti-inflammatory drug commonly used for leprosy and skin disorders. These symptoms, including fever, hepatitis, dermatitis, and lymphadenopathy, resolved with appropriate treatment.
Introduction
Dapsone, known for its antibiotic and anti-inflammatory properties, is a medication prescribed for leprosy and certain skin conditions. However, it can lead to drug-induced hypersensitivity syndrome, characterized by fever and multiorgan failure. Although rare in Korean children, cases have been reported.
Case report
After taking dapsone for skin issues, an 11-year-old Korean child developed itchy rashes and fever. Initial tests revealed low white blood cell count and enlarged liver and spleen. Despite complications like pneumonia and kidney problems, the patient showed improvement with treatment.
Discussion
Dapsone, a sulfone similar to sulfonamides originally used as dyes, is now utilized for leprosy and various dermatological conditions.
When administered orally, dapsone is quickly absorbed and metabolized in the liver by P450 enzymes. Hypersensitivity syndrome and other adverse effects may occur after several weeks of treatment.
Treatment with systemic steroids, such as prednisolone, has proven effective for dapsone-induced hypersensitivity syndrome.
For further insights and updates, access articles and summaries published on this platform. Stay informed about advancements in the field with alerts and promotions.
Allergologia et Immunopathologia welcomes submissions related to asthma, allergies, and childhood immunology. The journal, affiliated with the Spanish Society of Pediatric Allergy and Clinical Immunology, covers a wide range of clinical and research topics.
This study aimed to highlight cases of children allergic to clavulanic acid despite prior tolerance to amoxicillin. The diagnosis process and recommended treatment options were discussed.
Results
Out of the 10 children who underwent the oral provocation test with cefuroxime axetil, 8 of them showed positive reactions, confirming their allergy to clavulanic acid. This suggests a high correlation between A-CL allergy and sensitivity to cefuroxime axetil.
Additionally, the study found that patients with a history of penicillin allergy were more likely to develop A-CL allergy, indicating a possible cross-reactivity between penicillin and clavulanic acid.
Further research is needed to understand the mechanisms of A-CL allergy and to explore alternative treatment options for patients with this condition.